Disease‐specific phenotypes in iPSC ‐derived neural stem cells with POLG mutations
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چکیده
منابع مشابه
Reversal of Cellular Phenotypes in Neural Cells Derived from Huntington’s Disease Monkey-Induced Pluripotent Stem Cells
Huntington's disease (HD) is a dominant neurodegenerative disorder caused by the expansion of glutamine residues in the N-terminal region of the huntingtin (HTT) protein. The disease results in progressive neuronal loss, leading to motor, cognitive, and psychiatric impairment. Here, we report the establishment of neural progenitor cell (NPC) lines derived from induced pluripotent stem cells (iP...
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ژورنال
عنوان ژورنال: EMBO Molecular Medicine
سال: 2020
ISSN: 1757-4676,1757-4684
DOI: 10.15252/emmm.202012146